Source:http://www.reactome.org/biopax/48887BiochemicalReaction4811
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Authored: D'Eustachio, P, 2004-02-13 16:27:00,
Edited: D'Eustachio, P, Jassal, B, 0000-00-00 00:00:00,
The irreversible conversion of adenylosuccinate to adenosine 5'-monophosphate and fumarate is catalyzed by adenylosuccinate lyase. The active form of this enzyme is a cytosolic tetramer (Stone et al. 1993). The enzyme also catalyzes the conversion of 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) to 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) and fumarate. Humans lacking the enzyme accumulate dephosphorylated forms of both substrates, indicating that the enzyme mediates both reactions in vivo as well (Race et al. 2000).
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Adenylosuccinate => AMP + Fumarate
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adenylosuccinate => adenosine 5'-monophosphate + fumarate
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4.3.2.2
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