Source:http://www.reactome.org/biopax/48887BiochemicalReaction4681
| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
Authored: May, B, 2009-06-08,
Edited: May, B, 2009-06-08,
FFAR1 (GPR40) is a G-protein coupled receptor. Based on studies with inhibitors of G proteins such as pertussis toxin FFAR1 is believed to signal through Gq/11. Binding of free fatty acids by FFAR1 activates the heterotrimeric Gq complex, which then activates Phospholipase C. From experiments in knockout mice it is estimated that signaling through FFAR1 is responsible for about 50% of the augmentation of insulin secretion produced by free fatty acids. The rest of the augmentation is due to metabolism of the free fatty acids within the pancreatic beta cell.,
Reviewed: Kebede, M, 2009-09-09,
Reviewed: Madiraju, MS, 2009-10-02,
Reviewed: Poitout, V, 2009-09-09
|
| biopax3:xref |
http://identifiers.org/pubmed/12496284,
http://identifiers.org/pubmed/15914509,
http://identifiers.org/pubmed/16081037,
http://identifiers.org/pubmed/17101212,
http://identifiers.org/pubmed/17130640,
http://identifiers.org/pubmed/17395749,
http://identifiers.org/pubmed/18606873,
http://identifiers.org/pubmed/18827341,
http://identifiers.org/pubmed/19398560,
urn:biopax:UnificationXref:REACTOME DATABASE ID_416530,
urn:biopax:UnificationXref:REACTOME_REACT_19346_4
|
| biopax3:dataSource | |
| biopax3:displayName |
Activation of Gq by Fatty Acid Receptor 1: Fatty Acid Complex
|
| biopax3:left | |
| biopax3:right |