Source:http://www.reactome.org/biopax/48887BiochemicalReaction4675
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Authored: May, B, 2009-05-28 03:44:04,
Edited: May, B, 2009-05-28 03:44:04,
Reviewed: Gillespie, ME, 2009-06-02 00:56:21,
The binding of acetylcholine to the Muscarinic Acetylcholine Receptor M3 activates the heterotrimeric G protein, Gq, associated with the M3 receptor. Activation occurs through protein-protein interaction and results in the alpha subunit of Gq exchanging GDP for GTP (i.e releasing GDP and binding GTP). The 3 subunits of the G protein then dissociate into an alpha:GTP complex and a beta:gamma complex.
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| biopax3:xref |
http://identifiers.org/pubmed/11588141,
http://identifiers.org/pubmed/12194018,
http://identifiers.org/pubmed/16753580,
http://identifiers.org/pubmed/16871065,
http://identifiers.org/pubmed/17900700,
http://identifiers.org/pubmed/17919190,
http://identifiers.org/pubmed/18383439,
http://identifiers.org/pubmed/8190105,
urn:biopax:UnificationXref:REACTOME DATABASE ID_399995,
urn:biopax:UnificationXref:REACTOME_REACT_18309_4
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Activation of Gq by Muscarinic Acetylcholine Receptor M3
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