Source:http://www.reactome.org/biopax/48887BiochemicalReaction4661
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Authored: Garapati, P V, 2012-01-11,
DGL-CoA (8,11,14-eicosatrienoyl-CoA) undergoes desaturation by delta 5-desaturase (D5-desaturase) forming arachidonoyl-CoA (AA-CoA, 5,8,11,14-Eicosatetraenoic acid). D5-desaturase has 62% sequence identity with D6-desaturase but desaturates a different carbon atom, adding a double bond at position C5 in arachidonoyl-CoA (AA-CoA). AA can be metabolized by variety of oxygenases (including cyclo-oxygenase and lipoxygenase systems) to form a family of varying products known as eicosanoids, prostaglandins, leukotrines and thromboxanes thus playing important role in inflamation response.,
Edited: Garapati, P V, 2012-01-11
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Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA
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