Source:http://www.reactome.org/biopax/48887BiochemicalReaction4659
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Authored: Garapati, P V, 2012-01-11,
Edited: Garapati, P V, 2012-01-11,
The first major step in the metabolism of linoleic acid (LA) is desaturation of delta 9,12-octadecadienoyl CoA/linoleoyl CoA (LA-CoA) to delta 6,9,12-octodecatrienoyl CoA/gamma-lenoleoyl CoA (GLA-CoA). This step is catalyzed by delta-6-destaurase (fatty acid desaturase-2, FADS2) which introduces a cis-double bond between carbons 6 and 7. This is the rate limiting step in LA metabolism (Horrobin 1993).
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Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA
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1.14.19.3
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