Source:http://www.reactome.org/biopax/48887BiochemicalReaction4647
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Authored: Garapati, P V, 2012-01-11,
Edited: Garapati, P V, 2012-01-11,
Eicosapentaenoyl-CoA (EPA-CoA) is transformed to docosapentaenoyl-CoA (DPA-CoA/clupanodonic acid; 7,10,13,16,19-22:5(n-3)) by addition of two carbon atoms from malanoyl-CoA. This reaction is catalyzed by the enzymes ELOVL5/2 (Leonard et al. 2004). DPA is quite high in seal oil and may act as an anti-atherogenic factor. DPA has 10-fold greater endothelial cell migration ability than EPA, which is important in wound-healing processes. DPA may act as a precursor for production of the DPA-related D-series of resolvins or neuroprotectins (Kaur et al. 2011).
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http://identifiers.org/pubmed/12323085,
http://identifiers.org/pubmed/12323090,
http://identifiers.org/pubmed/14636670,
http://identifiers.org/pubmed/20655949,
http://identifiers.org/pubmed/8832760,
urn:biopax:UnificationXref:REACTOME DATABASE ID_2046100,
urn:biopax:UnificationXref:REACTOME_REACT_121058_1
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Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA
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