Source:http://www.reactome.org/biopax/48887BiochemicalReaction4576
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At the early endosome membrane, type I (INPP4A) (Norris et al. 1995, Ivetac et al. 2005) and type II inositol-3,4-bisphosphate 4-phosphatase (INPP4B) (Norris et al. 1997) colocalise with early and recycling endosomes through their C2 domains which bind to the phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) present in these membranes. It is here that phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) is dephosphorylated by INPP4A/B to phosphatidylinositol 3-phosphate (PI3P).,
Authored: Williams, MG, 2011-10-18,
Edited: Williams, MG, 2011-08-12,
Reviewed: Wakelam, Michael, 2012-05-14
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PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane
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3.1.3.66
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