Source:http://www.reactome.org/biopax/48887BiochemicalReaction4562
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At the plasma membrane, phosphatidylinositol 5-phosphatases dephosphorylate phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) to phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2). The phosphatidylinositol 5-phosphatases involved are: inositol polyphosphate 5-phosphatase K (INPP5K) aka SKIP (Ijuin et al. 2000, Gurung et al. 2003), phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (INPP5J) aka PIPP (Gurung et al. 2003, Mochizuki & Takenawa 1999), phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (INPP5D) aka SHIP1 (Drayer et al. 1995, Kavanaugh et al. 1996, Dunant et al. 2000), and phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 (INPPL1) aka SHIP2 (Habib et al. 1998, Wisniewski et al. 1999, Pesesse et al. 2001).,
Authored: Williams, MG, 2011-10-18,
Edited: Williams, MG, 2011-08-12,
Reviewed: Wakelam, Michael, 2012-05-14
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biopax3:xref |
http://identifiers.org/pubmed/10194451,
http://identifiers.org/pubmed/10593988,
http://identifiers.org/pubmed/10753883,
http://identifiers.org/pubmed/10822173,
http://identifiers.org/pubmed/11349134,
http://identifiers.org/pubmed/12536145,
http://identifiers.org/pubmed/8723348,
http://identifiers.org/pubmed/8769125,
http://identifiers.org/pubmed/9660833,
urn:biopax:UnificationXref:REACTOME DATABASE ID_1675949,
urn:biopax:UnificationXref:REACTOME_REACT_120976_1
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PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane
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