Linked Life Data

48887BiochemicalReaction4561

Source:http://www.reactome.org/biopax/48887BiochemicalReaction4561

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
biopax3:comment
At the plasma membrane, phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (PIP5K1A), beta (PIP5K1B), and gamma (PIP5K1C) phosphorylate phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) to produce phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3). This is a minor reaction, however, and its physiological role is uncertain.<br><br>The following lists the above proteins with their corresponding literature references: PIP5K1A (Zhang et al. 1997, Tolias et al. 1998), PIP5K1B (Zhang et al. 1997, Tolias et al. 1998), and PIP5K1C (Wenk et al. 2001, Di Paolo et al. 2002, Krauss et al. 2003)., Authored: Williams, MG, 2011-10-18, Edited: Williams, MG, 2011-08-12, Reviewed: Wakelam, Michael, 2012-05-14
biopax3:xref
biopax3:dataSource
biopax3:displayName
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
biopax3:left
biopax3:right