Source:http://www.reactome.org/biopax/48887BiochemicalReaction4559
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biopax3:comment |
At the plasma membrane, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits form complexes with regulatory subunits. These complexes phosphorylate phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) to phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) (Stephens et al. 1997). The PI(4,5)P2 3-kinase complexes involved are: PI(4,5)P2 3-kinase catalytic subunit alpha isoform (PIK3CA) bound to PI 3-kinase regulatory subunit alpha/beta/gamma (PIK3R1/2/3); beta (PIK3CB) bound to PIK3R1/2/3; delta (PIK3CD) bound to PIK3R1/2/3; and gamma (PIK3CG) bound to PI 3-kinase regulatory subunit 5 (PIK3R5) or 6 (PIK3R6).<br><br>The following lists the above proteins with their corresponding literature references: PIK3CA:PIK3R1, PIK3CA:PIK3R2, PIK3CA:PIK3R3 (Dey et al. 1998, Vanhaesebroeck et al. 1997, Meier et al. 2004); PIK3CB:PIK3R1, PIK3CB:PIK3R2, PIK3CB:PIK3R3 (Meier et al. 2004); PIK3CD:PIK3R1, PIK3CD:PIK3R2, PIK3CD:PIK3R3 (Vanhaesebroeck et al. 1997, Meier et al. 2004); and PIK3CG:PIK3R5, PIK3CG:PIK3R6 (Voigt et al. 2006, Suire et al. 2005, Stoyanov et al. 1995).,
Authored: Williams, MG, 2011-10-18,
Edited: Williams, MG, 2011-08-12,
Reviewed: Wakelam, Michael, 2012-05-14
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biopax3:xref |
http://identifiers.org/pubmed/15135396,
http://identifiers.org/pubmed/15797027,
http://identifiers.org/pubmed/16476736,
http://identifiers.org/pubmed/7624799,
http://identifiers.org/pubmed/9094719,
http://identifiers.org/pubmed/9113989,
http://identifiers.org/pubmed/9524259,
urn:biopax:UnificationXref:REACTOME DATABASE ID_1676048,
urn:biopax:UnificationXref:REACTOME_REACT_121297_1
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biopax3:displayName |
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
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biopax3:eCNumber |
2.7.1.153
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