Linked Life Data

48887BiochemicalReaction4558

Source:http://www.reactome.org/biopax/48887BiochemicalReaction4558

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
biopax3:comment
At the plasma membrane, Synaptojanin-1 (SYNJ1) and -2 (SYNJ2), inositol polyphosphate 5-phosphatase K (INPP5K) aka SKIP, phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (INPP5J) aka PIPP dephosphorylate phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) to form phosphatidylinositol 4-phosphate (PI4P). SYNJ1/2 both have an N-terminal Sac1-like domain, a central 5-phosphatase domain and a C-terminal proline-rich segment, with this latter part being the most divergent part of the protein sequence.<br><br>The following lists the above proteins with their corresponding literature references: SYNJ1 (Johenning et al. 2004, Haffner et al. 1997, Guo et al. 1999, Mani et al. 2007), SYNJ2 (Malecz et al. 2000), INPP5K (Injuin et al. 2000, Gurung et al. 2003), and INPP5J (Gurung et al. 2003, Mochizuki & Takenawa 1999)., Authored: Williams, MG, 2011-10-18, Edited: Williams, MG, 2011-08-12, Reviewed: Wakelam, Michael, 2012-05-14
biopax3:xref
biopax3:dataSource
biopax3:displayName
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane
biopax3:eCNumber
3.1.3.36
biopax3:left
biopax3:right