Source:http://www.reactome.org/biopax/48887BiochemicalReaction4372
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Authored: Jassal, B, 2008-05-19 12:57:01,
Cholesterol, NADPH + H+, and O2 react to form 27-hydroxycholesterol, H2O, and NADP+, in the mitochondrial matrix, catalyzed by CYP27A1. 27-Hydroxycholesterol is the most abundant oxysterol in the plasma in humans; its formation is thought to play a central role in the mobilization of cholesterol from non-hepatic tissues.,
Edited: D'Eustachio, P, 2007-04-30 14:43:26,
Reviewed: D'Eustachio, P, 2008-05-28 08:30:54
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Cholesterol is hydroxylated to 27-hydroxycholesterol by CYP27
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cholesterol + NADPH + H+ + O2 => 27-hydroxycholesterol + H2O + NADP+
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