Source:http://www.reactome.org/biopax/48887BiochemicalReaction433
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Authored: D'Eustachio, P, 2008-11-29 15:37:01,
Edited: D'Eustachio, P, 2008-11-29 15:37:01,
Reviewed: Jassal, B, 2008-11-26 09:32:08,
SLC7A7 as a heterodimer with SLC3A2 in the plasma membrane mediates the exchange of arginine for leucine and a sodium ion. The physiological concentrations of arginine and leucine are expected to favor arginine export. By the criterion of Northern blotting, SLC7A6 is predominantly expressed in the kidney (Pfeiffer et al. 2000).
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SLC7A7 (y+LAT1)-mediated exchange of extracellular leucine for cytosolic arginine
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