Source:http://www.reactome.org/biopax/48887BiochemicalReaction4322
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Authored: Jassal, B, 2007-01-19 10:34:59,
Edited: D'Eustachio, P, 2007-02-17 19:40:28,
Reviewed: D'Eustachio, P, 2007-04-30 14:43:26,
THCA (25(R) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate), coenzyme A, and ATP react to form the CoA conjugate of 25(R) THCA, AMP, and pyrophosphate. This cytosolic reaction is catalyzed by SLC27A2 (VLCS). SLC27A5 (BACS) also catalyzes this reaction; the relative contributions of the two enzymes to de novo bile acid synthesis in vivo are not certain (Mihalik et al. 2002).
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THCA is conjugated with Coenzyme A (SLC27A2 VLCS)
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THCA + ATP + CoASH => 25(R) THCA-CoA + AMP + pyrophosphate (SLC27A2 "VLCS")
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6.2.1.3
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