Source:http://www.reactome.org/biopax/48887BiochemicalReaction4245
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Authored: May, B, 2009-05-30 16:45:51,
Edited: May, B, 2009-05-30 16:45:51,
Edited: May, B, 2009-06-08,
In the absence of activating ligands of PPAR-alpha, the PPAR-alpha:RXR-alpha heterodimers recruit corepressors NCoR1, NCoR2(SMRT), and histone deacetylases (HDACs) to genes regulated by PPAR-alpha. The corepressors maintain chromatin at the gene in an inactive conformation and prevent expression of the gene.,
Reviewed: Kersten, S, 2009-06-08
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| biopax3:xref |
http://identifiers.org/pubmed/10529898,
http://identifiers.org/pubmed/11330046,
http://identifiers.org/pubmed/16476485,
http://identifiers.org/pubmed/16503871,
http://identifiers.org/pubmed/18288277,
http://identifiers.org/pubmed/18292238,
urn:biopax:UnificationXref:REACTOME DATABASE ID_400183,
urn:biopax:UnificationXref:REACTOME_REACT_19283_1
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Recruitment of Corepressors by PPARA:RXRA Heterodimer
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