Source:http://www.reactome.org/biopax/48887BiochemicalReaction4171
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Authored: Joshi-Tope, G, 2003-10-23 17:11:00,
Cytosolic fatty acid synthase (FAS) complex catalyzes the reaction of acetyl-CoA with 7 malonyl-CoA and 14 NADHP + 14 H+ to form a molecule of palmitate and 7 CO2, 14 NADP+, 8 CoASH, and 6 H2O. The process proceeds via the successive condensations of malonyl groups onto the growing acyl chain,each followed by loss of CO2 and three steps of reduction (Smith et al. 2003).
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Conversion of malonyl-CoA and acetyl-CoA to palmitate
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acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O
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2.3.1.85
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| biopax3:participantStoichio... |
http://www.reactome.org/biopax/48887Stoichiometry13561,
http://www.reactome.org/biopax/48887Stoichiometry13562,
http://www.reactome.org/biopax/48887Stoichiometry13563,
http://www.reactome.org/biopax/48887Stoichiometry13564,
http://www.reactome.org/biopax/48887Stoichiometry13565,
http://www.reactome.org/biopax/48887Stoichiometry13566,
http://www.reactome.org/biopax/48887Stoichiometry13567
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| biopax3:right |