Source:http://www.reactome.org/biopax/48887BiochemicalReaction4169
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Authored: Gopinathrao, G, 2003-10-03 00:00:00,
Cytosolic acetyl-CoA carboxylase 1 (ACACA) catalyzes the reaction of bicarbonate, ATP, and acetyl-CoA to form malonyl-CoA, ADP, and orthophosphate. The reaction is positively regulated by citrate. The human ACACA cDNA has been cloned (Abu-Elheiga et al. 1995) and the biochemical properties of the human enzyme have recently been described (Cheng et al. 2007; Locke et al. 2008). Four ACACA isoforms generated by alternative splicing have been identified as mRNAs - the protein product of the first has been characterized experimentally.
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Formation of Malonyl-CoA from Acetyl-CoA (liver)
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acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate
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6.4.1.2
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