Source:http://www.reactome.org/biopax/48887BiochemicalReaction4142
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Authored: D'Eustachio, P, 2008-05-12 17:46:52,
CETP (cholesterol ester transfer protein) complexed with triacylglycerol interacts with a spherical HDL (high density lipoprotein) particle, acquiring cholesterol ester molecules and donating triacylglycerol to the HDL (Swenson et al. 1988; Morton and Zilversmit 1983). This process is reversible but in the body proceeds in the direction annotated here. A model for the lipid exchange process has been proposed based on recent studies of the structure of CETP:lipid complexes (Qiu et al. 2007).,
Edited: D'Eustachio, P, 2008-06-13 14:03:50,
Reviewed: Jassal, B, 2008-06-13 14:05:49
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CETP-mediated lipid exchange: spherical HDL gains triacylglycerol
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CETP:triacylglycerol complex + spherical HDL <=> CETP:cholesterol ester complex + spherical HDL:triacylglycerol
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