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Authored: D'Eustachio, P, 2008-06-02 20:10:30, Edited: D'Eustachio, P, 2008-06-02 20:10:30, Reviewed: Jassal, B, 2008-06-03 13:06:01, The plasma membrane transport protein SLC6A12 (BGT-1) mediates the uptake of GABA (gamma-aminobutyrate) and betaine and, less efficiently, of diminobutyrate (DABA) and beta-alanine. Together with each amino acid molecule, 3 sodium ions and 2 chloride ions are taken up. In the body, SLC6A12 is expressed in the proximal tubules of the kidney and cells of the central nervous system (Rasola et al. 1995; Matskevitch et al. 1999).
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SLC6A12 (BGT-1)-mediated uptake of GABA and betaine
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