Source:http://www.reactome.org/biopax/48887BiochemicalReaction3864
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Authored: Lorca, T, Castro, A, 2006-01-26 00:00:00,
Edited: Matthews, L, 2004-11-18 13:25:08,
Edited: Matthews, L, 2006-02-17 00:25:47,
One model ( the direct inhibition model) describing the inhibition of the APC/C during the mitotic spindle checkpoint suggests that the association of the hBUBR1:hBUB3:MAD2*:CDC20 mitotic checkpoint complex (MCC) with APC/C results in the inactivation of APC/C. The affinity between MCC and APC/C is not high, thus inhibition is readily reversible when the mitotic spindle checkpoint has been satisfied.,
Reviewed: Peters, JM, 2006-03-27 22:55:09
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Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1
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