Source:http://www.reactome.org/biopax/48887BiochemicalReaction3844
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After the initiation of DNA condensation during mitosis, NuMA is phosphorylated by Cdc2 kinase and transported rapidly to the centrosomal region (Hsu and Yeh, 1996). Another phosphorylation event occurs when NuMA associates with the mitotic spindle (Gaglio et al., 1995; Hsu and Yeh, 1996). While p34cdc2/cyclin B-dependent phosphorylation appears to plays an essential role in the targeting of NuMA to the spindle apparatus (Compton and Luo, 1995)(Hsu and Yeh, 1996), there may be additional protein kinases that promote the release of NuMA from the nuclear compartment at nuclear envelope breakdown (Saredi et al., 1997).,
Authored: Matthews, L, 2008-11-11 14:53:40,
Edited: Matthews, L, 2008-11-09 05:12:41,
Reviewed: Merdes, A, 2008-11-17 13:55:29
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Cyclin B/Cdk1 mediate phosphorylation of NuMA
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2.7.11.22
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