Source:http://www.reactome.org/biopax/48887BiochemicalReaction3843
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Authored: Matthews, L, 2008-11-11 14:53:40,
Edited: Matthews, L, 2008-11-09 05:12:41,
Plk1 is associated with the centrosomes early in mitosis (Golsteyn et al. 1995). Plk1 activity is necessary for the maturation of centrosomes at the G2/M transition and the establishment of a bipolar spindle (Lane and Nigg 1996). Specific inhibitors against Plk1 or silencing of Plk1 produce a monopolar mitotic apparatus (Sumara et al, 2004, van Vugt et al, 2004, McInnes et al, 2006, Peters et al, 2006, Lénárt et al, 2007).,
Reviewed: Merdes, A, 2008-11-17 13:55:29
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| biopax3:xref |
http://identifiers.org/pubmed/15210710,
http://identifiers.org/pubmed/15458642,
http://identifiers.org/pubmed/17028580,
http://identifiers.org/pubmed/17028581,
http://identifiers.org/pubmed/17291761,
http://identifiers.org/pubmed/7790358,
http://identifiers.org/pubmed/8991084,
urn:biopax:UnificationXref:REACTOME DATABASE ID_380311,
urn:biopax:UnificationXref:REACTOME_REACT_15470_1
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Recruitment of Plk1 to centrosomes
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