Source:http://www.reactome.org/biopax/48887BiochemicalReaction3840
| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
Authored: Lee, KS, 2004-12-08 21:18:23,
Edited: Gillespie, ME, 0000-00-00 00:00:00,
It has been shown that Xenopus polo homolog,Plx1, directly phosphorylates and activates Cdc25C, which in turn dephosphoryates and activates Cdc2. This step is critical for the onset of mitosis. Since Plx1-dependent Cdc25C phosphorylation occurs in the absence of Cdc2 activity, it is likely that Plx1 is a triggering kinase, which leads to the activation of Cdc2 and therefore the normal onset of mitosis.
|
| biopax3:xref | |
| biopax3:dataSource | |
| biopax3:displayName |
Activation of Cdc25C
|
| biopax3:left | |
| biopax3:right |