Source:http://www.reactome.org/biopax/48887BiochemicalReaction3833
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The rapid translocation of cyclin B1:Cdc2 from the cytoplasm to the nucleus at the onset of mitosis is a result of an increase in the rate of import and, likely, a decreased rate of export. The increased rate of nuclear import is dependent upon phosphorylation of the CRS which creates a nuclear import signal in the amino terminus of cyclin B1 (Hagting et al, 1999).
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Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes
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