Source:http://www.reactome.org/biopax/48887BiochemicalReaction3820
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Full activity of most CDKs is dependent on CAK mediated phosphorylation at a conserved residue (Thr 161 in Cdc2). This modification is thought to improve substrate binding. High affinity binding of Cyclin A within the Cyclin A:Cdc2 complex requires this phosphorylation (Desai et al 1995).
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CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes
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