Source:http://www.reactome.org/biopax/48887BiochemicalReaction3807
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Authored: Pagano, M, 2006-09-19 08:23:10,
Edited: Matthews, L, 2006-09-28 04:25:14,
Recognition of p27 by SCF(Skp2) and the subsequent ubiquitination of p27 is dependent upon Cyclin E/A:Cdk2-mediated phosphorylation of p27 at Thr 187 (Montagnoli et al., 1999). p21 is also phosphorylated at a specific site (Ser130) by Cyclin E/A:Cdk2, stimulating its ubiquitination. Unlike p27, however, p21 ubiquitination can take place in the absence of phosphorylation, although with less efficiency (Bornstein et al.,2003).,
Reviewed: Coqueret, O, 2006-10-06 08:59:06
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Cyclin A:Cdk2 mediated phosphorylation of p27/p21
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2.7.11.22
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