Source:http://www.reactome.org/biopax/48887BiochemicalReaction380
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Authored: Jassal, B, 2011-08-01,
Edited: Jassal, B, 2011-08-01,
Reviewed: D'Eustachio, P, 2011-08-23,
Some members of the ABC transporter superfamily are able to mediate the efflux of a broad range of cytotoxic drugs from cells, leading to the name multidrug resistance (MDR) proteins (Seeger and van Veen 2009). The ABCB1 (P-glycoprotein 1[PGP], multidrug resistance protein 1 [MRP1]) is the most characterised MDR (Shen et al. 1986, Gottesman & Pastan 1988). ABCB5 (Frank et al. 2005) and ABCA8 (Tsuruoka et al. 2002) are newer members of MDRs.
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| biopax3:xref |
http://identifiers.org/pubmed/12379217,
http://identifiers.org/pubmed/15899824,
http://identifiers.org/pubmed/19135557,
http://identifiers.org/pubmed/2900833,
http://identifiers.org/pubmed/3457471,
urn:biopax:UnificationXref:REACTOME DATABASE ID_1467457,
urn:biopax:UnificationXref:REACTOME_REACT_111164_1
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ABCA8, B1 and B5 mediate xenobiotic efflux
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3.6.3.44
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