Source:http://www.reactome.org/biopax/48887BiochemicalReaction3780
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As quiescent G0 cells reenter the cell cycle, p130 (RBL2) is phosphorylated by CDK4/6. This phosphorylated p130 (RBL2) binds ubiquitin ligase SCF (Skp2) in complex with Cks1, and is subsequently ubiquitinated and degraded similarly to p27, which is another target of SCF (Skp2).,
Authored: Orlic-Milacic, Marija, 2011-06-14,
Reviewed: MacPherson, D, 2011-08-25
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Ubiquitination of p130 (RBL2) by SCF (Skp2)
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| biopax3:eCNumber |
6.3.2.19
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