Source:http://www.reactome.org/biopax/48887BiochemicalReaction3774
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Edited: Matthews, L, 2005-10-07 06:13:50,
Prior to mitogen activation, the inhibitory proteins, INK4 (p15, p16, p18, and p19) associate with the catalytic domain of free CDK4/6, preventing its association with cyclin, and thus its activation.
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Association of INK4A with Cdk4/6
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