Source:http://www.reactome.org/biopax/48887BiochemicalReaction3731
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During G1, the activity of cyclin-dependent kinases (CDKs) is kept in check by the CDK inhibitors (CKIs) p27 and p21, thereby preventing premature entry into S phase (see Guardavaccaro and Pagano, 2006). The efficient recognition and ubiquitination of p27 by the SCF(Skp2) complex requires the formation of a trimeric complex containing p27 and cyclin E/A:Cdk2.,
Edited: Matthews, L, 2006-10-02 07:13:54
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Inactivation of Cyclin E:Cdk2 complexes by p27/p21
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