Source:http://www.reactome.org/biopax/48887BiochemicalReaction3663
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Authored: Luo, F, 2005-11-10 11:23:18,
Edited: Shamovsky, V, 2009-12-16,
Reviewed: Gay, NJ, 2006-04-24 16:48:17,
The mechanism of TBK1 or IKKi(epsilon) activation by TRIF is unclear. It was suggested that these protein kinases undergo autophosphorylation. The most recent study showed that phosphorylation and the activation of TBK1/ IKKi are catalyzed by a distinct protein kinase (Clark et al. 2009). Other studies demonstrated an essential role of TRAF3 in the activation of TBK1 (Hacker et al. 2006).<p>It was also shown that the ubiquitin like domain (ULD) of TBK1 and IKK-i, a regulatory component, is involved in the control of kinase activation, substrate presentation, and downstream signaling (Ikeda et al 2007).
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Recruitment of human TBK1/IKK epsilon to the Viral dsRNA:TLR3:TRIF Complex followed by their activation
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