Source:http://www.reactome.org/biopax/48887BiochemicalReaction3614
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Authored: D'Eustachio, P, 2012-02-03,
Edited: D'Eustachio, P, 2011-12-30,
Reviewed: Sudol, M, 2012-02-03,
YWHAE (14-3-3 epsilon) binds phosphorylated WWTR1 (TAZ), sequestering it in the cytosol. Structural studies indicate that the active form of YWHAE (14-3-3 epsilon) is a homodimer (Yang et al. 2006); the stoichiometry of its complex with WWTR1 (TAZ) is unknown and has been annotated arbitrarily here to involve one WWTR1 (TAZ) molecule and a YWHAE(14-3-3 epsilon) dimer. Phosphorylation of serine residue 127 of WWTR1 (TAZ) appears to be critical for YWHAE (14-3-3 epsilon) binding (Kanai et al. 2000; Lei et al. 2008).
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YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ)
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