Source:http://www.reactome.org/biopax/48887BiochemicalReaction3591
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Authored: D'Eustachio, P, 2012-02-03,
Cytosolic LATS1 and LATS2 are phosphorylated by phospho-STK3 (p-MST2). LATS proteins are known to form complexes with MOB1 proteins and this reaction is annotated with LATS:MOB1 complexes as its substrate. Likewise, phosphorylated (active) STK3 (p-MST2) and SAV1 are known to form a complex and that complex is annotated as the catalyst of this reaction. Serine-909 and threonine-1097 have been identified as LATS1 residues phosphorylated by STK4 kinase (MST1); STK3 (MST2) is inferred to act similarly. The target residues of LATS2 have not been identified experimentally but are inferred to be serine-871 and threonine-1041 based on sequence similarity (Chan et al. 2005).,
Edited: D'Eustachio, P, 2011-12-30,
Reviewed: Sudol, M, 2012-02-03
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Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)
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2.7.11
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