Source:http://www.reactome.org/biopax/48887BiochemicalReaction3524
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Edited: Jupe, S, 2009-09-09,
p115-RhoGEF is a potent GTPase activating protein (GAP) for both G alpha 12 and G alpha 13 subunits. More importantly, the interaction between activated G alpha 13 (but not G alpha 12) triggers p115-RhoGEF activity. While this pathway may important in vivo, in prostate-derived PC-3 cells RNAi mediated knockdown of p115-RhoGEF levels had no effect on the response to thrombin (PMID: 15143072).
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G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)
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