Source:http://www.reactome.org/biopax/48887BiochemicalReaction3511
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Authored: Jassal, B, 2008-11-07 12:17:32,
Edited: Jupe, S, 2010-05-26,
G alpha q protein (or Gq/11) consists of four family members (G-alpha 11, -alpha 14, -alpha 15 and -alpha q). It activates phospholipase C (PLC) (Dowal L et al, 2006). PLC hydrolyzes phosphatidylinositol (PIP2) to diacyl glycerol (DAG) and inositol triphosphate (IP3). DAG acts as a second messenger that activates protein kinase C (PKC) and IP3 can bind to IP3 receptors, particular calcium channels in the endoplasmic reticulum (ER). Calcium flow causes the cytosolic concentration of calcium to increase, causing a cascade of intracellular changes and activity.,
Reviewed: D'Eustachio, P, 2008-11-29 18:33:05
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http://identifiers.org/pubmed/10191087,
http://identifiers.org/pubmed/16754659,
http://identifiers.org/pubmed/1905813,
http://identifiers.org/pubmed/3086311,
http://identifiers.org/pubmed/8664309,
urn:biopax:UnificationXref:REACTOME DATABASE ID_379048,
urn:biopax:UnificationXref:REACTOME_REACT_15291_6
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Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
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