Source:http://www.reactome.org/biopax/48887BiochemicalReaction3504
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Authored: Jupe, S, 2009-02-26 15:51:29,
Edited: Jupe, S, 2010-05-26,
Reviewed: D'Eustachio, P, 2010-05-21,
The liganded receptor undergoes a conformational change, generating a signal that is propagated in a manner that is not completely understood to the the G-protein. This stimulates the exchange of GDP for GTP in the G-protein alpha subunit, activating the G-protein.
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Liganded Gz-activating GPCR acts as a GEF for Gz
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