Source:http://www.reactome.org/biopax/48887BiochemicalReaction3502
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Authored: Jupe, S, 2010-05-18,
Edited: Jupe, S, 2010-05-26,
Reviewed: D'Eustachio, P, 2010-05-21,
The classical model of G-protein signaling suggests that the G-protein dissociates upon GPCR activation. The active G alpha (i) subunit then participates in signaling, until its intrinsic GTPase activity degrades the bound GTP to GDP. The inactive G alpha (i):GDP complex has much higher affinity for the G beta:gamma complex and consequently reassociates.
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Inactive G alpha (i) reassociates with G beta:gamma
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