Source:http://www.reactome.org/biopax/48887BiochemicalReaction3498
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Authored: Jupe, S, 2010-05-18,
Edited: Jupe, S, 2010-05-26,
Reviewed: D'Eustachio, P, 2010-05-21,
The classical view of G-protein signalling is that the G-protein alpha subunit dissociates from the beta:gamma dimer. Activated G alpha (i) and the beta:gamma dimer then participate in separate signaling cascades. Although G protein dissociation has been contested (e.g. Bassi et al. 1996), recent in vivo experiments have demonstrated that dissociation does occur, though possibly not to completion (Lambert 2008).
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The Ligand:GPCR:Gi complex dissociates
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