Source:http://www.reactome.org/biopax/48887BiochemicalReaction3496
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Authored: Jupe, S, 2010-05-18,
Edited: Jupe, S, 2010-05-26,
Many unrelated GPCRs couple with the Gi G-protein subtype. The G-alpha (i) subunit inhibits the production of cAMP from ATP. In turn, this results in decreased activity of cAMP-dependent protein kinase. There are 8 types of G-alpha (i) known to date:G(i)1, G(i)2, G(i)3, G(i)o, G(i)z, G(i)gust (gustducin) and two G(i)t (retinal transducin) (Downes GB and Gautam N, 1999). Once GDP is exchanged for GTP on the alpha subunit, it dissociates from the G-beta-gamma subunit.,
Reviewed: D'Eustachio, P, 2010-05-21
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Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
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