Source:http://www.reactome.org/biopax/48887BiochemicalReaction3431
| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
Authored: Jassal, B, 2009-03-26 15:30:13,
Edited: Jassal, B, 2009-03-26 15:30:13,
Reviewed: D'Eustachio, P, 2009-05-29 07:44:22,
The dihydroxy-leukotriene, leukotriene B4 (LTB4) stimulates neutrophil chemotaxis and secretion. Chemotaxis, the principal effects of LTB4 and related dihydroxy-acids on leukocytes, occurs via activation of BLT (1 and 2) receptors (Yokomizo T et al, 1997; Yokozimo T et al, 2000). BLT2 is expressed ubiquitously, in contrast to BLT1, which is expressed predominantly in leukocytes. These receptors mediate their actions by coupling to G protein alpha q/11 subunits (McLeish KR et al, 1989) which activate a phosphatidylinositol-calcium second messenger system.
|
| biopax3:xref | |
| biopax3:dataSource | |
| biopax3:displayName |
BLT receptors can bind LTB4
|
| biopax3:left | |
| biopax3:right |