Source:http://www.reactome.org/biopax/48887BiochemicalReaction3428
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Authored: Jassal, B, 2009-04-02 10:56:26,
Edited: Jassal, B, 2009-04-02 10:56:26,
Prostacyclin (PGI2) prevents formation of the platelet plug involved in primary hemostasis (a part of blood clot formation) and is an effective vasodilator. Binding to its receptor, IP (Boie Y et al, 1994), allows coupling to and activation of the G protein alpha s subunit, which leads to activation of cAMP and increase in protein kinase A (PKA) activity (Schwaner I et al, 1995).,
Reviewed: D'Eustachio, P, 2009-05-29 07:44:22
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IP receptor can bind prostacyclin
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