Source:http://www.reactome.org/biopax/48887BiochemicalReaction3402
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Authored: Jupe, S, 2009-10-27,
Edited: Jupe, S, 2010-03-01,
Reviewed: D'Eustachio, P, 2009-12-11,
Urotensin-II (U2) is a vasoactive 'somatostatin-like' cyclic peptide originally isolated from fish spinal cords. It was found to activate GPR14 later renamed Urotensin II receptor (U2R). <br> U2 is the most potent known vasoconstrictor. A second ligand for U2R, urotensin-related peptide or Urotensin 2B, was identified as an extract from rat brains, and shown to activate rat and human U2R.
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Urotensin-2 receptor binds urotensin-2 and 2B
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