Source:http://www.reactome.org/biopax/48887BiochemicalReaction3387
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Authored: Jassal, B, 2009-01-07 14:37:24,
Edited: Jassal, B, 2009-01-07 14:37:24,
Reviewed: D'Eustachio, P, 2009-03-02 09:24:35,
The orexin (hypocretin) neuropeptides (A and B) both derive from a 131 residue precursor, prepro-orexin peptide (Sakurai T et al, 1999). Orexin A (Takai T et al, 2006) binds preferentially to the orphan GPCR orexin 1 receptor (Sakurai T et al, 1998). This activated complex can transduce its signal via the Gq class of G protein.
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Orexin 1 receptor can bind orexin-A neuropeptide
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