Source:http://www.reactome.org/biopax/48887BiochemicalReaction3385
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Authored: Jassal, B, 2008-12-18 15:01:49,
Edited: Jassal, B, 2008-12-18 15:01:49,
Reviewed: D'Eustachio, P, 2009-03-02 09:24:35,
The KiSS1-derived peptide receptor, GPR54 is a galanin-like GPCR (Lee DK et al, 1999) that can bind kisspeptin-54 (metastin), a natural ligand of the receptor (Kotani M et al, 2001). The GPR54 gene appears to be essential for normal puberty and gonadotropin-released hormone physiology (Seminara SB et al, 2003). Metastin is encoded by the KiSS-1 metastasis suppressor gene, a 54-amino acid peptide that suppresses metastases of human melanomas and breast carcinomas without affecting tumorigenicity (Ohtaki T et al, 2001).
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The Kiss receptor GPR54 binds kisspeptin
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