Source:http://www.reactome.org/biopax/48887BiochemicalReaction3371
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Authored: Jassal, B, 2008-11-24 14:25:55,
Edited: Jassal, B, 2008-11-24 14:25:55,
Reviewed: D'Eustachio, P, 2009-03-02 09:24:35,
Substance P (Harmar AJ et al, 1986) is an neuropeptide, 11 amino-acids in length, that acts as a neurotransmitter for pain response neurons. It does this by binding to its endogenous receptor neurokinin 1 (NK1R, substance P receptor) which belongs to the tachykinin receptor sub-family of GPCRs (Takeda Y et al, 1991).
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Tachykinin receptor 1 (NK1) binds to substance P
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