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48887BiochemicalReaction3370

Source:http://www.reactome.org/biopax/48887BiochemicalReaction3370

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Authored: Jassal, B, 2008-08-21 14:07:16, Edited: D'Eustachio, P, 2008-09-01 11:58:31, Reviewed: Bockaert, J, 2008-09-01 12:04:13, Somatostatin (growth hormone inhibiting hormone, GHIH; somatotropin release-inhibiting factor, SRIF) (Shen LP et al, 1992) is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with somatostatin receptors 1-5 (Hoyer D et al, 1995). Somatostatin has two active forms produced by alternative cleavage of the single preproprotein and named according to the number of amino acids in the chain; Somatostatin-28 and somatostatin-14. The 5 receptors known to date all couple with pertussis toxin-sensitive G proteins to inhibit adenylate cyclase after ligand binding. They were classified according to the dates they were discovered; SSTR1 and 2 (Yamada Y et al, Jan. 1992), SSTR3 (Yamada Y et al, Dec. 1992) and SSTR4 and SSTR5 (Yamada Y et al, Sep. 1993).
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Somatostatin receptors bind somatostatin
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