Source:http://www.reactome.org/biopax/48887BiochemicalReaction3352
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Authored: Jassal, B, 2008-08-21 14:07:16,
Edited: D'Eustachio, P, 2008-09-01 11:58:31,
Reviewed: Bockaert, J, 2008-09-01 12:04:13,
The orphan nociceptin (ORL1) receptor (Mollereau C et al, 1994) is most closely related to opioid receptors on structural (sequence) and functional grounds but is not a typical opioid receptor. It may play a role in instinctive behaviours and emotions. Its natural ligand is nociceptin (orphanin FQ) (Mollereau C et al, 1996), a 17 amino acid neuropeptide which acts as a potent anti-analgesic. Both receptor and ligand are widely expressed in the CNS.
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Nociceptin receptor binds to nociceptin
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