Source:http://www.reactome.org/biopax/48887BiochemicalReaction3317
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Authored: Egan, SE, Orlic-Milacic, M, 2011-11-14,
Binding of NOTCH1 to CNTN1 (contactin-1) is followed by gamma-secretase mediated cleavage of NOTCH1 at the S3 cleavage site and accumulation of NICD1 in the nucleus. Cleavage of NOTCH1 by ADAM10/17 at the S2 cleavage site, which should precede the S3 cleavage by gamma-secretase, has not been studied in the context of NOTCH1 activation by CNTN1. NOTCH activation by CNTN1 is deltex-dependent, but the exact mechanism for action of the NOTCH:DTX complex has not yet been elucidated.,
Edited: D'Eustachio, P, 2012-02-06,
Edited: Orlic-Milacic, M, 2012-02-10,
Reviewed: Haw, R, 2012-02-06
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Cleavage of CNTN1:NOTCH1 complex releases NICD1
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