Source:http://www.reactome.org/biopax/48887BiochemicalReaction3265
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Authored: Orlic-Milacic, M, 2012-04-04,
Edited: Jassal, B, 2012-04-10,
Reviewed: Huang, Tao, 2012-05-14,
SMURF1 (Ebisawa et al. 2001), SMURF2 (Kavsak et al. 2000) or NEDD4L (Kuratomi et al. 2005) ubiquitin ligases, recruited to TGF-beta receptor complex through interaction with SMAD7, ubiquitinate both SMAD7 and/or TGF-beta receptor I (TGFBR1), targeting the complex for degradation. This was inferred from experiments using a recombinant mouse Smad7 with recombinant human ubiquitin ligases and TGF-beta receptors.
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SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7
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6.3.2.19
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