Source:http://www.reactome.org/biopax/48887BiochemicalReaction3261
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After SMAD7:SMURF1 complex binds to XPO1 (CRM1) through the nuclear export signal (NES) in the C-terminus of SMURF1, XPO1 enables transport of SMAD7:SMURF1 to the cytosol (Suzuki et al. 2002, Tajima et al. 2003). A recombinant mouse Smad7 and recombinant human SMURF1 were used in these experiments.,
Authored: Heldin, CH, Moustakas, A, Huminiecki, L, Jassal, B, 2006-02-02,
Edited: Jassal, B, 2012-04-10,
Reviewed: Huang, Tao, 2012-05-14
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SMAD7:SMURF1 complex is exported to the cytosol
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